Metabolism of Steroids in the Foetus BIOSYNTHESIS OF 60c-HYDROXYTESTOSTERONE IN THE HUMAN FOETAL LIVER
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چکیده
Schubert, Wehrberger & Frankenberg (1964) first isolated and identified 6a-hydroxytestosterone as a metabolite in human urine after intravenous administration oftestosterone to adult women. The tissue site of O6c-hydroxylation was unknown, and it could not be excluded that the metabolite had arisen by epimerization of 6fl-hydroxytestosterone. Recently we demonstrated that testosterone is hydroxylated in positions 1,, 2,B, 6,B and 18 after incubations with microsomes from livers of midpregnancy foetuses (Gustafsson & Lisboa, 1968; Lisboa & Gustafsson, 1968, 1969a). Minor amounts of two other unknown C1903 steroids with a 3-oxoA4 structure were also found in these incubation studies. One of them has now been isolated and characterized as 6a-hydroxytestosterone.
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